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EGFR-TKI

2023.09

Efficacy, safety and dose selection of AZD3759 in patients with untreated EGFR-mutated non-small-cell lung cancer and central nervous system metastases in China (CTONG1702-Arm 8): a multi-center, single-arm, phase 2 trial

The Lancet, Si-Yang Maggie Liu et al

2018.03

Enhanced efficacy of AZD3759 and radiation on brain metastasis from EGFR mutant non-small cell lung cancer

Int J Cancer, Xue Li et al

2017.10

Activity and safety of AZD3759 in EGFR-mutant non-small-cell lung cancer with CNS metastases (BLOOM): a phase 1, open-label, dose-escalation and dose-expansion study

Lancet Respir Med, Myung-Ju Ahn et al

2016.12

AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases

Sci Transl Med, Zhenfan Yang et al

2015.10

Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

J Med Chem, Qingbei Zeng et al

细胞治疗

2022.02

Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia

Science Translational Medicine, Berrien-Elliot et al

2021.12

Donor Memory-like NK cells Persist and Induce Remissions in Pediatric Patients with Relapsed AML after Transplant

Blood, Bednarski et al

2021.07

A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy

Cancer Immunol Res, Becker-Hapak et al

2021.06

Memory-like Differentiation Enhances NK Cell Responses to Melanoma

Clin Cancer Res, Marin et al

2020.12

Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia

Cancer Discovery, Berrien-Elliott et al

2020.11

CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas

Blood, Gang et al

2020.10

Memory-like natural killer cells for cancer immunotherapy

Seminars in Hematology, Gang et al

2019.10

Chimeric antigen receptor T cells (CAR-T) for the treatment of T-cell malignancies

Best Pract Res Clin Haematol, Mathew Cooper et al

2018.10

CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells

Leukemia, Alcantara et al

2018.02

An “off-the-shelf” fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

Leukemia, Cooper et al

2017.03

Cytokine-Induced Memory-Like Differentiation Enhances Unlicensed Natural Killer Cell Antileukemia and FcγRIIIa-Triggered Responses

Biol Blood Marrow Transplant, Wagner et al

2016.09

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

Science Translational Medicine, Romee et al

2014.04

Preactivation with IL-12, IL-15, and IL-18 Induces CD25 and a Functional High-Affinity IL-2 Receptor on Human Cytokine-Induced Memory-like Natural Killer Cells

Biol Blood Marrow Transplant, Leong et al

2012.12

Cytokine activation induces human memory-like NK cells

Blood, Romee et al

产品管线

EGFR-TKI

Efficacy, safety and dose selection of AZD3759 in patients with untreated EGFR-mutated non-small-cell lung cancer and central nervous system metastases in China (CTONG1702-Arm 8): a multi-center, single-arm, phase 2 trial

Enhanced efficacy of AZD3759 and radiation on brain metastasis from EGFR mutant non-small cell lung cancer

Activity and safety of AZD3759 in EGFR-mutant non-small-cell lung cancer with CNS metastases (BLOOM): a phase 1, open-label, dose-escalation and dose-expansion study

AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases

Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

细胞治疗

Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia

Donor Memory-like NK cells Persist and Induce Remissions in Pediatric Patients with Relapsed AML after Transplant

A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy

Memory-like Differentiation Enhances NK Cell Responses to Melanoma

Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia

CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas

Memory-like natural killer cells for cancer immunotherapy

Chimeric antigen receptor T cells (CAR-T) for the treatment of T-cell malignancies

CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells

An “off-the-shelf” fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

Cytokine-Induced Memory-Like Differentiation Enhances Unlicensed Natural Killer Cell Antileukemia and FcγRIIIa-Triggered Responses

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

Preactivation with IL-12, IL-15, and IL-18 Induces CD25 and a Functional High-Affinity IL-2 Receptor on Human Cytokine-Induced Memory-like Natural Killer Cells

Cytokine activation induces human memory-like NK cells

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